- Gene Overview
- Interaction Network
- Sequence Verification
CEL, carboxyl ester lipase
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The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]
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Gene Synonyms (bile salt-activated lipase, bile salt-dependent lipase, oncofetal isoform, bucelipase, carboxyl ester hydrolase, carboxyl ester lipase (bile salt-stimulated lipase), cholesterol esterase, fetoacinar pancreatic protein, lysophospholipase, pancreatic, sterol esterase, BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8,)
- NCBI Gene ID:
1056
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>O75612
UNIPROT ID#>>X6R868
UNIPROT ID#>>B4DSX9
UNIPROT ID#>>Q86SR3
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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carboxyl ester lipase interacts with:
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