CXCL11, C-X-C motif chemokine ligand 11

CXCL11, C-X-C motif chemokine ligand 11

• Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

• Gene Synonyms (C-X-C motif chemokine 11, beta-R1, chemokine (C-X-C motif) ligand 11, interferon gamma-inducible protein 9, interferon-inducible T-cell alpha chemoattractant, small inducible cytokine B11, small inducible cytokine subfamily B (Cys-X-Cys), member 11, small inducible cytokine subfamily B (Cys-X-Cys), member 9B, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1,)
• NCBI Gene ID: 6373
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14625
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-X-C motif chemokine ligand 11 interacts with:

• leucine rich repeat kinase 2
  microtubule associated scaffold protein 2
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.