Maxwell® RSC 48 Instrument
Automated Nucleic Acid Purification of 1 to 48 Samples
- High-quality nucleic acid purification with minimal steps and less hands-on time
- Purifies 1–48 samples in a single run
- Intuitive software and integrated vision system for detecting and preventing deck tray setup errors
Catalog Number:
Size
Catalog Number: AS8500
Extract High-Quality Nucleic Acids with Less Hands-On Time
The Maxwell® RSC 48 Instrument is a compact, automated nucleic acid purification platform that processes up to 48 samples simultaneously. Using Maxwell® RSC prefilled cartridges, the Maxwell® RSC 48 Instrument brings the same consistent, reliable purification of DNA or RNA from a variety of sample types and a higher throughput. The intuitive graphical interface makes the instrument easy to use. The integrated vision system with its large LED indicator reduces the potential for user error by detecting proper cartridge placement and lets you know before a run starts if there is an issue. An integrated Bar Code reader makes it easy to track samples.

Francis Crick Institute Case Study:
Benchtop Automated Nucleic Acid Purification


It saves me in total about 40 minutes per 12 samples, and I do 4 runs per day, so that is almost half a day.
Yan Tsou, Laboratory Research Scientist
Anthony Nolan Research Institute Case Study:
Long-Read Next-Generation Sequencing Workflow


It really is the workhorse of our lab in terms of DNA extraction… allowing us to process multiple samples at once with minimal hands-on time.
Thomas Turner, Senior Post Doctoral Research Scientist
No Drips, Plugs or Sample Loss with a Paramagnetic Particle Mover
The Maxwell® RSC DNA or RNA extraction methods start with cartridges prefilled with purification reagents and paramagnetic particles, ready for your samples. After sample addition, the Maxwell® RSC moves the paramagnetic particles and associated nucleic acids through multiple steps ultimately yielding highly pure RNA or DNA in 30–100µl.
Because the Maxwell® RSC is a magnetic particle mover, not a liquid handler, it offers advantages over other automated systems. There is minimal risk of cross-contamination because no liquid handling or splashing happens during sample processing. With no clogs and fewer breakdowns, there are fewer disruptions to your workflow.

Easy-to-Use Interface Simplifies Your RNA or DNA Extraction Workflow

Track samples easily
The integrated barcode reader records important information such as sample ID, kit ID and kit lot number.

Touch screen to begin the process
The intuitive touch screen interface lets you easily set up your purification run.

Prepare sample cartridges
Place prepared cartridges in the Maxwell® RSC 48. Press “Start” to purify 1–48 samples using the selected kit’s preprogrammed method.

Start run with confidence
The integrated vision system detects proper cartridge setup along with a large LED indicator and audible alarm, giving you confidence your extraction is running smoothly.
Find the Maxwell® RSC Kit for Your Sample Type

Whole Blood
Buffy Coat & Bone Marrow
Serum or Plasma
Stabilized Saliva

Cells
Tissue
FFPE
Plant Tissue
Multiple Human Sample Types
Find Protocols Tailored to Your Research Needs
Explore over 130 application notes* showcasing protocols and purification data for a broad range of sample types. Our growing library of application notes expand the flexibility of our kits to support your unique research needs.
*Application notes referenced here are For Research Use Only. Not for Use in Diagnostic Procedures.
If you do not find a protocol for your sample type or other specific sample extraction needs, please contact techserv@promega.com. We can help you find the best method for your needs.
Instrument Standard Components


A. Maxwell® RSC 48 Instrument
B. Tablet PC preloaded with Maxwell® RSC 48 Application Software
C. Power Supply for Tablet PC (Power Cord for Tablet PC provided separately)
D. USB Cable - Maxwell® RSC 48 Instrument to Tablet PC
E. Power Cable for Maxwell® RSC 48 Instrument (provided separately)
F. Maxwell® RSC 48 Deck Trays (2)
G. Hand held barcode reader
H. USB cable for connection of the Maxwell® RSC 48 Instrument to the barcode reader
UV Bulb (installed)
Quick Start Guide
Setup Guide
Accessories Available Separately
Additional deck trays, plungers and an optional bar code reader are available for purchase separately.
Instrument Specifications
Processing Time | 30–70 minutes (depending on sample type and method) |
Sample Capacity | 1–48 Samples; (2) 24 position, removable trays |
Weight | ~60 lbs (~27 kg) |
Dimensions | 21W × 21D × 14H inches (533 .4 × 533.4 × 355.6 mm) |
Main Power Voltage | 100–240V AC, 50/60Hz; autosensing; 4 Amps |
Operating Environment | 15–25°C |
UV Bulb | Average lifetime approximately 9,000 hours, length 212.1mm, diameter 16mm, 6W, 0.17A current, 42V, spectral peak F 253.7, UV output 1.7W |
Specifications
Catalog Number:
SDS
Search for SDSCertificate of Analysis
Use Restrictions
For Research Use Only. Not for Use in Diagnostic Procedures.Storage Conditions
Services & Support
One Call Supports It All

One Call Supports It All
We can support you with:
- Virtual and on-site consultations
- Data analyses
- Summary reports
Maintenance

Maintenance
If you want regular servicing and maintenance, we've got you covered. In addition to standard maintenance contracts, we also offer extended service packages to keep your instrument running smoothly beyond the warranty period.
Minimal Downtime

Minimal Downtime
To ensure minimal downtime, we offer:
- Field Support
- Loaner Programs
- Service Packages
- IQ and OQ Packages
Warranty Service Options
Warranty Benefit | Standard | Premier |
---|---|---|
Period | 1 Year | 1 Year |
Parts and Labor | Yes | Yes |
Field Support* | No, available for purchase separately | Yes, 1–2 business days |
Loan Instrument** | Yes, 5–7 business days | Yes, 1–2 business days |
Annual Preventive Maintenance | No, available for purchase separately | Yes, includes one preventive maintenance service |
Service Agreement Options
Service Agreement Benefit | Standard | Premier |
---|---|---|
Period | 1-, 2-, or 3-year service agreements (renewable) | 1-, 2-, or 3-year service agreements (renewable) |
Parts and Labor | Yes | Yes |
Field Support* | No, available for purchase separately | Yes, 2 business days |
Loan Instrument** | Yes, 5–7 business days | Yes, 1–2 business days |
Annual Preventive Maintenance | No, available for purchase separately | Yes, once every 12 months |
*May not be available in all countries; service response time may vary by geographical locations.
**The response time is calculated from when Technical Services determines a loaner instrument to be necessary following triage of the initial incident.
Find Protocols Tailored to Your Research Needs
Explore over 130 application notes* showcasing protocols and purification data for a broad range of sample types. Our growing library of application notes expand the flexibility of our kits to support your unique research needs.

*Application notes referenced here are For Research Use Only. Not for Use in Diagnostic Procedures.
Resources
Articles
Software and Firmware
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Extracts DNA from whole blood samples using the Maxwell® RSC Instrument.
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Purifies RNA from 1–16 whole blood samples using a low elution volume and the Maxwell® RSC Instrument.
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Maxwell® RSC miRNA from Tissue or Plasma and Serum Kits
In combination with the Maxwell® RSC Instrument, the kit purifies high-quality total RNA with an enhanced miRNA enrichment.
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