DPP4, dipeptidyl peptidase 4

DPP4, dipeptidyl peptidase 4

• The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

• Gene Synonyms (ADABP, ADCP2, CD26, DPPIV, TP103, dipeptidyl peptidase 4, ADCP-2, DPP IV, Gly-Pro naphthylamidase, Post-proline dipeptidyl aminopeptidase IV, T-cell activation antigen CD26, Xaa-Pro-dipeptidylaminopeptidase, adenosine deaminase complexing protein 2, dipeptidyl peptidase IV, dipeptidylpeptidase 4, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2),)
• NCBI Gene ID: 1803
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P27487
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dipeptidyl peptidase 4 interacts with:

• BCL10 immune signaling adaptor
  C3 and PZP like alpha-2-macroglobulin domain containing 8
  caspase recruitment domain family member 11
  C-C motif chemokine ligand 11
  C-C motif chemokine ligand 22
  C-C motif chemokine ligand 3 like 1
  C-C motif chemokine ligand 5
  C-X-C motif chemokine ligand 10
  C-X-C motif chemokine ligand 11
  C-X-C motif chemokine ligand 12
  C-X-C motif chemokine ligand 9
  C-X-C motif chemokine receptor 4
  dickkopf WNT signaling pathway inhibitor 1
  dipeptidyl peptidase 4
  epidermal growth factor receptor
  fibroblast activation protein alpha
  gastrin releasing peptide
  inhibitor of nuclear factor kappa B kinase subunit beta
  protein tyrosine phosphatase receptor type C
  testis expressed 101
  ubiquitin specific peptidase 22

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.